Diagnostic Significance of Pleural Fluid pH
نویسندگان
چکیده
The pH, PCW and bicarbonate levels were measured in 178 pleural effusions grouped according to preset criteria into various diagnostic categories. The pH and Pcoz were found to vary widely, the ranges being 6.80 to 7.60 and 26 to 126 mm Hg, respectively. The effusions associated with pneumonia (parapneumonk effusions) showed the most widely varying values of pH. Apparently the pleural fluid pH has predictive value for the course of parapneumonic effusions. Therapy consisting of antibiotics and thoracentesis alone was inadequate to effect resolution of any of the five parapneumonic effusions with a pH of less than 7.20. None of these five effusions was grossly purulent. On the other hand, all 19 parapneumonic effusions with a pH greater than 7.20 resolved with antibiotic therapy, without tube drainage. The mean pH of tuberculous effusions was significantly lower than the mean pH of malignant effusions. When these two possibilities exist, a pH below 7.30 is highly suggestive of tuberculosis, while a pH greater than 7.40 is highly suggestive of malignancy. It is concloded that the measurement of pleural fluid pH is useful in the diagnosis and management of pleural effusions.
منابع مشابه
The diagnostic value of pleural fluid pH.
One hundred eighty-three patients had simultaneous blood and pleural fluid pH determinations. Thirty-six effusions were transudates, and 147 were exudates. In 46 effusions, the pleural fluid pH was less than 7.30; all 46 were exudates. A pleural fluid pH less than 7.30 was associated with the following six diagnoses: (1) empyema; (2) malignancy; (3) collagen vascular disease; (4) tuberculosis; ...
متن کاملThe Diagnostic Values of Protein to Lactate Dehyrogenase Ratio in Serum and Pleural Fluid in Exudate Pleural Effusions
Introduction: Different etiologies of pleural effusion are diagnosed based on serum and plural fluid characteristics. The aim of this study was to assess and compare the serum and pleural fluid protein to lactate dehyrogenase (Pr/LDH) ratio in exudative pleural effusions. Materials and Methods: This study was conducted on 60 patients with exudative pleural effusion including: 20 cases with para...
متن کاملPleural fluid analysis in malignant mesothelioma. Prognostic implications.
Pleural fluid characteristics of 26 patients diagnosed with malignant mesothelioma over an 18-year period were reviewed and compared with those of patients with effusions due to other malignancies. Survival from time of initial thoracentesis was directly correlated with pleural pH and decreased pleural fluid/serum glucose ratios but was not related to protein or LDH concentration. Decreased ple...
متن کاملDiagnostic Value of Measurement Specific Gravity by Refractometric and Dipstick Method in Differentiation between Transudate and Exudate in Pleural and Peritoneal Fluid
Background: Accumulation of pleural and peritoneal fluid is seen in some diseases. In order to diagnose the disease and start the treatment, one of the most important actions will be to differentiate between exudates and transudates. The objective of this study was to determine the diagnostic value of measuring the specific gravity of the fluid through...
متن کاملPleural fluid pH as a predictor of pleurodesis failure: analysis of primary data.
STUDY OBJECTIVES To determine the predictive accuracy of pH for identifying patients with malignant pleural effusions who will fail pleurodesis. DESIGN Analysis of published and unpublished individual patient-level data retrieved from a MEDLINE search and correspondence with primary investigators. STUDY SELECTION Studies that reported pleural fluid pH values and outcomes of pleurodesis for ...
متن کامل